Talk Cancer » Lung Cancer » Hydrazine sulfate use in fighting cancer
Hydrazine sulfate use in fighting cancer
Question:
– Hide quoted text — Show quoted text – Does anyone have any knowledge of, or even possibly, experience with, Hydrazine sulfate in the use of the regression of cancer? Studies were compiled by the Syracuse Cancer Research Institute/Dr. Joseph Gold on the effectiveness of Hydrazine sulfate in the successful reversal of weight loss and debilitation in some cancer patients. It was also discovered that Hydrazine sulfate regressed or stabilized tumors in some patients also. The studies that I have read about so far have mentioned primarily brain and lung cancers as far as regression or stabilization of tumors. One of my questions is: is this substance something that can be used in lymphomas (my mother has Non-Hodgkins lymphoma)? She has not had any problems with weight loss so far; on the contrary, she is still overweight and is concerned that this substance, if used, would actually increase her weight – she is mainly looking at Hydrazine sulfate for the tumor regression/stabilization properties. Interferon was suggested to her for the same reasons, but she isn’t too crazy about the idea of this because of the possibly problematic side effects, and the constant trips to the doctor’s office to have it administered. My mother’s oncologist gave us a printout off of the internet about H.S. and tried to contact Dr. Gold by mail, but hasn’t had any luck so far. I believe this is somewhat new to him, also. We have tried to contact Dr. Gold by phone, but the receptionist stated that calls are not taken from patients, only medical personnel, so we are having a tough time getting any useful info on this. Our doctor’s office keeps giving us other numbers, but they are just pharmacy supply places or won’t give out a lot of info over the phone (without $). So far I haven’t been able to find anything specific to Hydrazine sulfate used with lymphoma on my internet searches either. As I understand it, H.S. does not need a prescription. The printout stated that it is a drug, but I was told by sellers of the substance that it is not a drug. Therefore, insurance probably will not cover it ($20 for 100 caps). ANY info would be much appreciated by my mom and I, or any other items on Non-Hodgkins would be good, too. She’s already had CHOP and fludarabine, and is interested in keeping her partial remission at bay. Thanks for any help, Doris BTW, stop by our WEB homepages Picture Atlas of Arizona and the Southwest & Images of Baja plus AstroLink at http://www.execpc.com/~drogge Doris Nerding/Dave Rogge
I think this is about the only doctor who is really pushing it. I’ve had patients take it, but only get sick on it. Did her oncologist give her the file on the lack of efficacy of hydrazine from the internet? H2
Response:
YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==HYDRAZINE SULFATE AND CANCERS== 3 AUTHOR Filov VA AUTHOR Gershanovich ML AUTHOR Danova LA AUTHOR Ivin BA TITLE Experience of the treatment with Sehydrin (Hydrazine Sulfate, HS) in the advanced cancer patients. SOURCE Invest New Drugs; VOL 13, ISS 1, 1995, P89-97 ABSTRACT The results of Sehydrin (Hydrazine Sulfate, HS) treatment of 740 patients with the advanced, recurrent or metastatic solid tumours of various localizations or malignant lymphomas, for whom all the methods of specific treatment (surgery, radiation, chemotherapy) had been exhausted are presented in this work. The objective response, symptomatic therapeutic effects and toxicity were estimated. Clinically significant objective responses were registered in patients with the soft tissue sarcomas, including neuroblastomas, and paradoxically–in such semimalignant tumours as desmoids. Although the objective response in patients with the lung cancer (90%–non-small cell) was only 4%, stabilization of long duration was registered in 22% of cases connected with the impressive relief of heavy common symptoms in 38.5% of the treated patients. Such a subjective response was established in 46.6% of all the 740 cases. The drug given per os was well tolerated by patients in primary and subsequent courses and did not induce myelosuppression or other significant side effects. On the basis of observations available, Sehydrin may be assessed as an alternative drug for the treatment and symptomatic therapy of patients with some advanced solid tumours and malignant lymphomas at a disease stage when the other methods of treatment can not be used. A possible mechanism of antitumour and symptomatic action is being discussed. 4 AUTHOR Loprinzi CL AUTHOR Goldberg RM AUTHOR Su JQ AUTHOR Mailliard JA AUTHOR Kuross SA AUTHOR Maksymiuk AW AUTHOR Kugler JW AUTHOR Jett JR AUTHOR Ghosh C AUTHOR Pfeifle DM AUTHOR et al TITLE Placebo-controlled trial of hydrazine sulfate in patients with newly diagnosed non-small-cell lung cancer [see comments] SOURCE J Clin Oncol; VOL 12, ISS 6, 1994, P1126-9 ABSTRACT PURPOSE: Hydrazine sulfate, an agent that appears to inhibit gluconeogenesis, has been studied in cancer patients for approximately 20 years. There was a recent resurgence of interest in this drug when subset analysis of a small placebo-controlled, double-blind, clinical trial reported improved survival among non-small-cell lung cancer patients with a good performance status who were randomized to receive this drug along with standard chemotherapy. PATIENTS AND METHODS: Patients on this trial had newly diagnosed, unresectable non-small-cell lung cancer and were treated with cisplatin and etoposide. In addition, they were randomized to receive hydrazine sulfate or placebo in a double-blind manner. RESULTS: A total of 243 patients were randomized. Response rates were similar in the two treatment arms. There were trends for worse time to progression and survival in the hydrazine sulfate arm. No significant differences were noted in the two study arms with regard to toxicity or quality of life (QL). CONCLUSION: This trial failed to demonstrate any benefit for patients who received hydrazine sulfate. 5 AUTHOR Loprinzi CL AUTHOR Kuross SA AUTHOR O’Fallon JR AUTHOR Gesme DH Jr AUTHOR Gerstner JB AUTHOR Rospond RM AUTHOR Cobau CD AUTHOR Goldberg RM TITLE Randomized placebo-controlled evaluation of hydrazine sulfate in patients with advanced colorectal cancer [see comments] SOURCE J Clin Oncol; VOL 12, ISS 6, 1994, P1121-5 ABSTRACT PURPOSE: Hydrazine sulfate is a controversial agent that was originally studied in cancer patients approximately 20 years ago. Based on a series of recent trials that suggested that this drug might have utility in cancer patients, we conducted this study. PATIENTS AND METHODS: Patients with metastatic colorectal cancer were randomized to receive hydrazine sulfate or placebo in a double-blinded manner. Protocol patients did not concurrently receive any other systemic antineoplastic treatment. RESULTS: There were 127 assessable patients entered onto this clinical trial. Data from the study showed trends both for poorer survival and for poorer quality of life (QL) in the hydrazine group. There were no significant differences in the two study arms with regard to anorexia or weight loss. CONCLUSION: This trial failed to demonstrate any benefit for hydrazine sulfate. 10 AUTHOR Chlebowski RT AUTHOR Bulcavage L AUTHOR Grosvenor M AUTHOR Oktay E AUTHOR Block JB AUTHOR Chlebowski JS AUTHOR Ali I AUTHOR Elashoff R TITLE Hydrazine sulfate influence on nutritional status and survival in non-small-cell lung cancer. SOURCE J Clin Oncol; VOL 8, ISS 1, 1990, P9-15 ABSTRACT This randomized, prospective, placebo-controlled clinical trial compares the influence on nutritional status and survival of hydrazine sulfate with placebo addition to cisplatin-containing combination chemotherapy in patients with unresectable non-small-cell lung cancer (NSCLC). The trial consisted of 65 patients with advanced, unresectable NSCLC who had had no prior chemotherapy, were at least partially ambulatory (Eastern Cooperative Oncology Group [ECOG] performance status [PS] level 0-2), and who had adequate hematologic, renal, and hepatic function. All patients received the same defined combination chemotherapy (cisplatin, vinblastine, and bleomycin) and the same defined dietary counseling with the addition of either three times daily oral hydrazine sulfate (60 mg) or placebo capsules. Hydrazine sulfate compared with placebo addition to chemotherapy resulted in significantly greater caloric intake and albumin maintenance (P less than .05). Considering all patients, survival was greater for the hydrazine sulfate compared with placebo group (median survival, 292 v 187 days), but the difference did not achieve statistical significance. In favorable PS patients (PS 0-1), survival was significantly prolonged (median survival, 328 days v 209 days; P less than .05) for hydrazine sulfate compared with
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Response:
Dear Dave and Doris, Have you checked out the website at<http://www.sph.uth.tmc.edu/www/utsph/utcam/index.htm ? It is a site containing all sorts of research materials about ‘alternative’ therapies. Does anyone have any knowledge of, or even possibly, experience with, Hydrazine sulfate in the use of the regression of cancer?
Hydrazine sulfate is an MAO inhibitor. It’s primary claim is it’s interuption of the cachexia/anorexia symptoms of cancer. There is no clinical proof that HS, in anyway, acts as a tumorcidal agent. Studies were compiled by the Syracuse Cancer Research Institute/Dr. Joseph Gold on the effectiveness of Hydrazine sulfate in the successful reversal of weight loss and debilitation in some cancer patients. It was also discovered that Hydrazine sulfate regressed or stabilized tumors in some patients also. The studies that I have read about so far have mentioned primarily brain and lung cancers as far as regression or stabilization of tumors.
Again, check out the above website. It’s from the U of Texas and contains much info on HS trials and testing. There’s alot of reading to be done at that site. – Hide quoted text — Show quoted text – One of my questions is: is this substance something that can be used in lymphomas (my mother has Non-Hodgkins lymphoma)? She has not had any problems with weight loss so far; on the contrary, she is still overweight and is concerned that this substance, if used, would actually increase her weight – she is mainly looking at Hydrazine sulfate for the tumor regression/stabilization properties. Interferon was suggested to her for the same reasons, but she isn’t too crazy about the idea of this because of the possibly problematic side effects, and the constant trips to the doctor’s office to have it administered. My mother’s oncologist gave us a printout off of the internet about H.S. and tried to contact Dr. Gold by mail, but hasn’t had any luck so far. I believe this is somewhat new to him, also. We have tried to contact Dr. Gold by phone, but the receptionist stated that calls are not taken from patients, only medical personnel, so we are having a tough time getting any useful info on this.
If your doctor provided you with a printout, (from which site?), he should also be able to discuss your mothers case with them via phone, I can provide three phone numbers to the SCRI, where Dr. Gold is the director. I don’t think I can post them to these NG’s, as I haven’t found out, yet, why one of my posts were removed from the NG alt.support.cancer, dated 3/5/97, but I believe it was because I posted a phone number to the SCRI. If you will request this info via personal e-mail, I will be happy to supply the phone #’s. Our doctor’s office keeps giving us other numbers, but they are just pharmacy supply places or won’t give out a lot of info over the phone (without $). So far I haven’t been able to find anything specific to Hydrazine sulfate used with lymphoma on my internet searches either.
Have you tried the NCI at 1-800-4cancer? As I understand it, H.S. does not need a prescription. The printout stated that it is a drug, but I was told by sellers of the substance that it is not a drug. Therefore, insurance probably will not cover it ($20 for 100 caps).
This is true, however, I strongly urge you to keep your doctor involved with all treatments, whether they be ‘alternative’ or not. Do not take the risk of drug reactions on your own. A doctor should and must be consulted, prior to any change of therapy. ANY info would be much appreciated by my mom and I, or any other items on Non-Hodgkins would be good, too. She’s already had CHOP and fludarabine, and is interested in keeping her partial remission at bay
My primary research has been with non small cell lung cancer. I don’t have much info(next to none) on Non-Hodgkins. However, there are many others in these NG’s with cancer similar to your mothers who will be more than happy to answer questions about Non-Hodgkins. . Thanks for any help,
Your welcome. Anytime. Sincerely, Larry Hamlin
Response:
Does anyone have any knowledge of, or even possibly, experience with, Hydrazine sulfate in the use of the regression of cancer? Studies were compiled by the Syracuse Cancer Research Institute/Dr. Joseph Gold on the effectiveness of Hydrazine sulfate in the successful reversal of weight loss and debilitation in some cancer patients. It was also discovered that Hydrazine sulfate regressed or stabilized tumors in some patients also. The studies that I have read about so far have mentioned primarily brain and lung cancers as far as regression or stabilization of tumors. One of my questions is: is this substance something that can be used in lymphomas (my mother has Non-Hodgkins lymphoma)? She has not had any problems with weight loss so far; on the contrary, she is still overweight and is concerned that this substance, if used, would actually increase her weight – she is mainly looking at Hydrazine sulfate for the tumor regression/stabilization properties. Interferon was suggested to her for the same reasons, but she isn’t too crazy about the idea of this because of the possibly problematic side effects, and the constant trips to the doctor’s office to have it administered. My mother’s oncologist gave us a printout off of the internet about H.S. and tried to contact Dr. Gold by mail, but hasn’t had any luck so far. I believe this is somewhat new to him, also. We have tried to contact Dr. Gold by phone, but the receptionist stated that calls are not taken from patients, only medical personnel, so we are having a tough time getting any useful info on this. Our doctor’s office keeps giving us other numbers, but they are just pharmacy supply places or won’t give out a lot of info over the phone (without $). So far I haven’t been able to find anything specific to Hydrazine sulfate used with lymphoma on my internet searches either. As I understand it, H.S. does not need a prescription. The printout stated that it is a drug, but I was told by sellers of the substance that it is not a drug. Therefore, insurance probably will not cover it ($20 for 100 caps). ANY info would be much appreciated by my mom and I, or any other items on Non-Hodgkins would be good, too. She’s already had CHOP and fludarabine, and is interested in keeping her partial remission at bay. Thanks for any help, Doris BTW, stop by our WEB homepages Picture Atlas of Arizona and the Southwest & Images of Baja plus AstroLink at http://www.execpc.com/~drogge Doris Nerding/Dave Rogge