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Interlekin-2 Question
Question:
If you are using low dose Il-2, say 500,000 units/day, how can you get multiple doses from a vial? The instructions say discard the vial after the first dose, but Il-2 is expensive and insurance does not pay. If a vial contains 18,000,000 units its very wasteful to throw away after single use of 500,000 units. How can you avoid this? Is there some preservative people use?
Response:
If you are using low dose Il-2, say 500,000 units/day, how can you get multiple doses from a vial? The instructions say discard the vial after the first dose, but Il-2 is expensive and insurance does not pay. If a vial contains 18,000,000 units its very wasteful to throw away after single use of 500,000 units. How can you avoid this? Is there some preservative people use?
A million units a day may be better…up to 3 million….have you asked Kendall Smith?? There should be a way. George M. Carter
Response:
If you are using low dose Il-2, say 500,000 units/day, how can you get multiple doses from a vial? The instructions say discard the vial after the first dose, but Il-2 is expensive and insurance does not pay. If a vial contains 18,000,000 units its very wasteful to throw away after single use of 500,000 units. How can you avoid this? Is there some preservative people use?
0.5 MIU / day (Million Internation Units per day) is very low even by Dr. Kendall A. Smith’s standards. He has been testing 2 MIU / day. Where did you hear about using only 0.5 MIU / day? (or how did you decide on it yourself?) How to get more than one dose out of a vial? Simple. Ignore the instructions. They are written for someone with cancer not HIV. Yes, the stuff spoils fast after being mixed but not so fast that I did not feel an effect even after using IL-2 from a vial that was 11 days old. I got Proleukin(R) brand recombinate IL-2 in 22 MIU vials which yeilds about 11 injections. It is suggested that you pre-fill all your syringes and leave them in the refrigerator. I used 0.5 cc insulin syringes.
Response:
Thank you for your reply. I have a paper by Kendall Smith from 1996 where he used 250,000 IU/m2/day (approx 500,000/ day) and increased gradually until systemic side effects occurred. No doubt Kendall Smith is using more these days. My concern is I have somewhat weak (i.e. normal, but barely) kidney function, but my plan was to increase the dose until I noticed side effects or elevated creatinine. The T-cell increase with 250,000/IU/m2/day was modest (27cells/mm/month), but DTH skin test to antigen doubled in diameter after 6 months. Did you have any side effects from 2 million/day? Flu-like symptoms? What about kidney function? How long did you stay on this before cycling off? Improvements in immune function? What do you guys think about adding high dose melatonin with IL-2 to improve the efficacy? – Hide quoted text — Show quoted text – If you are using low dose Il-2, say 500,000 units/day, how can you get multiple doses from a vial? The instructions say discard the vial after the first dose, but Il-2 is expensive and insurance does not pay. If a vial contains 18,000,000 units its very wasteful to throw away after single use of 500,000 units. How can you avoid this? Is there some preservative people use? 0.5 MIU / day (Million Internation Units per day) is very low even by Dr. Kendall A. Smith’s standards. He has been testing 2 MIU / day. Where did you hear about using only 0.5 MIU / day? (or how did you decide on it yourself?) How to get more than one dose out of a vial? Simple. Ignore the instructions. They are written for someone with cancer not HIV. Yes, the stuff spoils fast after being mixed but not so fast that I did not feel an effect even after using IL-2 from a vial that was 11 days old. I got Proleukin(R) brand recombinate IL-2 in 22 MIU vials which yeilds about 11 injections. It is suggested that you pre-fill all your syringes and leave them in the refrigerator. I used 0.5 cc insulin syringes.