Talk Cancer

Question:

In article <dZyO3.5826$%E3.214…@wbnws01.ne.mediaone.net>, "*Firewalk* Dan Torregrossa" <d…@firewalk.org> writes: >I dunno, it might just have a number code, it is made by Galsco-Welcome, or >whatever their name is, It’s till being tested and the FDA should approve it >by January 2k.  If I can find the name, I’ll be sure to post it. >Dan

The Glaxo drug is Alosetron (generic name) or Lotronex (what I think’ll be the brand name)… I may have those backwards. Press release: http://www.glaxowellcome.com/pr/may1998_ibs.html >Chris & Kerri Ritchie <critc…@erols.com> wrote in message >news:7uasug$ou8$1@autumn.news.rcn.net… >> What is the name of this drug? >> *Firewalk* Dan Torregrossa <d…@firewalk.org> wrote in message >> news:v2zN3.1097$%E3.43541@wbnws01.ne.mediaone.net… >> > ok, take this as you want, a post was sent up about a new IBS drug, it’s >> > supposed to work with a regular diet, and other meds, depending on your >> > situation, IBS-D, IBS-C, or IBS-C,D I talked to my doctor, she said it

The studies I’ve seen published says it’ll be primarily for IBS-D and mostly in women.  It works less consistantly well in men. >> > should be released to the general public, but I can start it early as a >> > human Guinea pig, YEY ME!  but hell, I’m not waiting for January 2K, my >> > luck, they won’t be able to ship it…thanks to Y2K buggies.  Any way, >the >> > one fallback that they have seen is, A: you’ll never be able to tell if >> you >> > have food poisoning, B: or the Flu, or if C: you drink, when you’ve had >> way >> > too much, causing Blood Alcohol poisoning, though I don’t expect too >many >> > problems with A or B, but C could really suck, Also, if you stop taking >> it, >> > the symptoms come back in a few hours, which sucks if you miss a dose

Title Review article: the safety and efficacy of alosetron, a 5-HT3 receptor antagonist, in female irritable bowel syndrome patients. Author Mangel AW; Northcutt AR Address Glaxo Wellcome Inc., Research Triangle Park, North Carolina. awm43…@glaxowellcome.com Source Aliment Pharmacol Ther, 13 Suppl 2():77-82 1999 May Abstract Irritable bowel syndrome (IBS) is one of the most common gastrointestinal-related conditions. In this review, the safety and efficacy of alosetron, a potent and selective 5-HT3 receptor antagonist, in the treatment of IBS are discussed. Alosetron has been shown to produce statistically significant improvements in abdominal pain, stool consistency, stool frequency and urgency in female IBS patients. By contrast, no consistent improvement has been seen in male IBS patients treated with alosetron. The only adverse event of note with alosetron was constipation, and this represents a class effect of 5-HT3 receptor antagonists. In conclusion, alosetron is a safe and effective treatment for female IBS patients. Language Eng Unique Identifier 99358376 ********************************************************* Access to power must be confined to those who are not in love with it. -Plato kmot…@aol.com

Response:

Thanks K…I couldn’t remember it…I just remembered my doctor calling it by it’s FDA code. Dan Full Body Cast www.fullbodycast.org KMottus <kmot…@aol.comspamtrap> wrote in message

news:19991018075823.21866.00000029@ngol03.aol.com… – Hide quoted text — Show quoted text -> In article <dZyO3.5826$%E3.214…@wbnws01.ne.mediaone.net>, "*Firewalk* Dan > Torregrossa" <d…@firewalk.org> writes: > >I dunno, it might just have a number code, it is made by Galsco-Welcome, or > >whatever their name is, It’s till being tested and the FDA should approve it > >by January 2k.  If I can find the name, I’ll be sure to post it. > >Dan > The Glaxo drug is Alosetron (generic name) or Lotronex (what I > think’ll be the brand name)… I may have those backwards. > Press release: > http://www.glaxowellcome.com/pr/may1998_ibs.html > >Chris & Kerri Ritchie <critc…@erols.com> wrote in message > >news:7uasug$ou8$1@autumn.news.rcn.net… > >> What is the name of this drug? > >> *Firewalk* Dan Torregrossa <d…@firewalk.org> wrote in message > >> news:v2zN3.1097$%E3.43541@wbnws01.ne.mediaone.net… > >> > ok, take this as you want, a post was sent up about a new IBS drug, it’s > >> > supposed to work with a regular diet, and other meds, depending on your > >> > situation, IBS-D, IBS-C, or IBS-C,D I talked to my doctor, she said it > The studies I’ve seen published says it’ll be primarily for IBS-D > and mostly in women.  It works less consistantly well in men. > >> > should be released to the general public, but I can start it early as a > >> > human Guinea pig, YEY ME!  but hell, I’m not waiting for January 2K, my > >> > luck, they won’t be able to ship it…thanks to Y2K buggies.  Any way, > >the > >> > one fallback that they have seen is, A: you’ll never be able to tell if > >> you > >> > have food poisoning, B: or the Flu, or if C: you drink, when you’ve had > >> way > >> > too much, causing Blood Alcohol poisoning, though I don’t expect too > >many > >> > problems with A or B, but C could really suck, Also, if you stop taking > >> it, > >> > the symptoms come back in a few hours, which sucks if you miss a dose > Title > Review article: the safety and efficacy of alosetron, a 5-HT3 receptor > antagonist, in female irritable bowel syndrome patients. > Author > Mangel AW; Northcutt AR > Address > Glaxo Wellcome Inc., Research Triangle Park, North Carolina. > awm43…@glaxowellcome.com > Source > Aliment Pharmacol Ther, 13 Suppl 2():77-82 1999 May > Abstract > Irritable bowel syndrome (IBS) is one of the most common > gastrointestinal-related conditions. In this review, the safety and > efficacy of alosetron, a potent and selective 5-HT3 receptor antagonist, > in the treatment of IBS are discussed. Alosetron has been shown to > produce statistically significant improvements in abdominal pain, stool > consistency, stool frequency and urgency in female IBS patients. By > contrast, no consistent improvement has been seen in male IBS patients > treated with alosetron. The only adverse event of note with alosetron > was constipation, and this represents a class effect of 5-HT3 receptor > antagonists. In conclusion, alosetron is a safe and effective treatment > for female IBS patients. > Language > Eng > Unique Identifier > 99358376 > ********************************************************* > Access to power must be confined to those who are > not in love with it. > -Plato > kmot…@aol.com

Response:

Based on the side effects you mentioned, it sounds pretty scary to me.  Can’t tell when you have food poisoning?  Just exactly what does that mean since there are so many agents that can cause what we call "food poisoning".

Response:

In article <19991022000539.17204.00000…@ng-cc1.aol.com>, olde…@aol.com (Oldeb23) writes: >Based on the side effects you mentioned, it sounds pretty scary to me.  Can’t >tell when you have food poisoning?  Just exactly what does that mean since >there are so many agents that can cause what we call "food poisoning".

Considering the vast majority of IBSers cannnot tell when they have food poisoning to start with…. We get a fair number of people here who have a sudden shift in symptoms consistant with food poisoning, who simply assume it is the IBS getting worse/different. I’m still really unclear what that means. If the drug completely shut down the ability of the body to exhibit symptoms of food poisoning, that would probably mean that the body is totally unable to defend itself against those organisms and "I don’t think a drug like that would pass the initial clinical trials. Let me see if I can find anything on medline that would suggest this problem….. The 5-HT receptors are involved in increasing water in the gut when you give Salmonella to pigs… that’s about all I could find. So the worst I could say about it is your diarrhea may be less sever if you got food poisoning and was on the new drug.   For me I still think the vomiting would be a dead giveaway. Based on my long-standing experience with histamine blockers, no drug that blocks receptors blocks all of them, or can totally override the bodies reactions to things (they can help, but most people on antihistamines will tell you that given enough allergen, they can still have a reaction, even on the best of medications). I have no clue why it’d alter you having the experience of having the flu, other than it would make the symptoms less severe, so you wouldn’t know you were sick. I don’t know why not suffering from symptoms would be a scary thing. As for alcohol, well with most of the drugs I’ve ever taken they pretty much all universally suggest staying off of alcohol, and I can’t really see what drinking to excess has to offer anywho. (although I vomit if I have drink #3 in the day, so maybe it is more enjoyable than it appears from the outside). And if it means you die at 3X the legal limit vs 4X… that’s a condition that is pretty easy to avoid (and if it isn’t, you need to seek professional help IMNSHO). It sounds like the doc was thinking of plausible side effects rather than reporting anything from the scientific literature. I’ll take a look around and see if I can get my hands on reported side effects from Clinical Trials.  (it isn’t  a bad thing to speculate on possible side effects, but if it merely serves to scare people from taking a potentially helpful drug… what concerned me more about the report is that the drug is clearly most effective in woman with diarrhea predominate IBS, and the gender differences, nor the type of IBS that it was for were mentioned. K. ********************************************************* Access to power must be confined to those who are not in love with it. -Plato kmot…@aol.com

Response:

ok, take this as you want, a post was sent up about a new IBS drug, it’s supposed to work with a regular diet, and other meds, depending on your situation, IBS-D, IBS-C, or IBS-C,D I talked to my doctor, she said it should be released to the general public, but I can start it early as a human Guinea pig, YEY ME!  but hell, I’m not waiting for January 2K, my luck, they won’t be able to ship it…thanks to Y2K buggies.  Any way, the one fallback that they have seen is, A: you’ll never be able to tell if you have food poisoning, B: or the Flu, or if C: you drink, when you’ve had way too much, causing Blood Alcohol poisoning, though I don’t expect too many problems with A or B, but C could really suck, Also, if you stop taking it, the symptoms come back in a few hours, which sucks if you miss a dose, in any case maybe the year 2K is the year IBS is eliminated, along with this Newsgroup!  It’s time we all end this war with IBS and our lives, I’m taking the heavy ammunition into battle…..anyone else, Viva the Revolution! Dan Torregrossa "Five Years, and I’m still living…I must like the pain" Oh and as god, and everyone here as my whitens, if this new drug does work, I will donate as much money as possible to Cancer Research — www.firewalk.org ICQ#6652169 "Fire Walk With Me."

Response:

I dunno, it might just have a number code, it is made by Galsco-Welcome, or whatever their name is, It’s till being tested and the FDA should approve it by January 2k.  If I can find the name, I’ll be sure to post it. Dan Chris & Kerri Ritchie <critc…@erols.com> wrote in message news:7uasug$ou8$1@autumn.news.rcn.net… – Hide quoted text — Show quoted text -> What is the name of this drug? > *Firewalk* Dan Torregrossa <d…@firewalk.org> wrote in message > news:v2zN3.1097$%E3.43541@wbnws01.ne.mediaone.net… > > ok, take this as you want, a post was sent up about a new IBS drug, it’s > > supposed to work with a regular diet, and other meds, depending on your > > situation, IBS-D, IBS-C, or IBS-C,D I talked to my doctor, she said it > > should be released to the general public, but I can start it early as a > > human Guinea pig, YEY ME!  but hell, I’m not waiting for January 2K, my > > luck, they won’t be able to ship it…thanks to Y2K buggies.  Any way, the > > one fallback that they have seen is, A: you’ll never be able to tell if > you > > have food poisoning, B: or the Flu, or if C: you drink, when you’ve had > way > > too much, causing Blood Alcohol poisoning, though I don’t expect too many > > problems with A or B, but C could really suck, Also, if you stop taking > it, > > the symptoms come back in a few hours, which sucks if you miss a dose, in > > any case maybe the year 2K is the year IBS is eliminated, along with this > > Newsgroup!  It’s time we all end this war with IBS and our lives, I’m > taking > > the heavy ammunition into battle…..anyone else, Viva the Revolution! > > Dan Torregrossa > > "Five Years, and I’m still living…I must like the pain" > > Oh and as god, and everyone here as my whitens, if this new drug does > work, > > I will donate as much money as possible to Cancer Research > > — > > www.firewalk.org > > ICQ#6652169 > > "Fire Walk With Me."

Response: