Talk Cancer

Question:

Nature. 2004 Nov 7 [Epub ahead of print] Links Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A. [1] Institute for Systems Biology, Seattle, Washington 98103, USA [2] Institute for Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway [3] These authors contributed equally to this work. Although iron is required to sustain life, its free concentration and metabolism have to be tightly regulated. This is achieved through a variety of iron-binding proteins including transferrin and ferritin. During infection, bacteria acquire much of their iron from the host by synthesizing siderophores that scavenge iron and transport it into the pathogen. We recently demonstrated that enterochelin, a bacterial catecholate siderophore, binds to the host protein lipocalin 2 (ref. 5). Here, we show that this event is pivotal in the innate immune response to bacterial infection. Upon encountering invading bacteria the Toll-like receptors on immune cells stimulate the transcription, translation and secretion of lipocalin 2; secreted lipocalin 2 then limits bacterial growth by sequestrating the iron-laden siderophore. Our finding represents a new component of the innate immune system and the acute phase response to infection. PMID: 15531878 [PubMed - as supplied by publisher] ————————————————————————– —— Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

Response:

You are seeing this message because Tom Hennessy aka ironjust…@aol.com has posted a message in alt.support.mult-sclerosis.  If you are new to this group then please understand that he appears to get his thrills from the misfortunes of other people, evidenced by his comments to the victims of forest fires, the passing of members of this newsgroup and his presence on all support newsgroups. In keeping with his personality, Tommy believes discussions in these groups are conducted by using off-colour language and name calling that would make a rattlesnake spew.  This personality trait is shown here: http://tinyurl.com/2cmto He seems to believe that whoever swears loudest and longest is the winner. In his mind, Hennessy believes he is a great researcher who has won a Nobel Prize.  In fact, he merely copies medical material from the web and pastes it to usenet, proudly calling this his research. There was a time when people like Tommy were institutionalized, now they are allowed to run for public office and post to usenet.  He is a fine example why a mental health unit should not obtain an internet account. Previous addresses include watch…@nucleus.com, thenn…@telus.net. darreltaylor…@hotmail.com. — Spelling and grammatical errors are deliberate to catch copyright violators.