Talk Cancer

Question:

J Neuroimmunol. 2004 Mar;148(1-2):146-53.  Related Articles, Links   alpha-Lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis. Morini M, Roccatagliata L, Dell’Eva R, Pedemonte E, Furlan R, Minghelli S, Giunti D, Pfeffer U, Marchese M, Noonan D, Mancardi G, Albini A, Uccelli A. Molecular Oncology Laboratory, National Cancer Research Institute, Genoa, Italy. alpha-Lipoic acid (alpha-LA) is a neuroprotective metabolic antioxidant that has been shown to cross the blood brain barrier. We tested whether alpha-LA is capable to prevent MOG35-55-induced experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). Daily oral administration of alpha-LA, starting at the time of immunization, significantly prevented EAE progression as compared to control mice. This was associated with a reduction of CNS infiltrating T cells and macrophages as well as decreased demyelination. We then tested alpha-LA in a therapeutic protocol aimed at suppressing EAE after its onset. Intraperitoneal (i.p.), but not oral, administration of alpha-LA significantly prevented disease progression when compared to vehicle-treated controls. Similarly, we observed significant reduction of demyelination and inflammatory infiltration. This clinical effect was not due to an impairment of MOG35-55 recognition by encephalitogenic T cells. In contrast, MOG-specific T cells showed a decreased production of IFNgamma and IL-4, suggesting an immunosuppressive activity on both Th1 and Th2 cytokines. In addition, alpha-LA inhibited the proteolytic activity of MMP2 and MMP9 only at very high doses. Our data indicate that alpha-LA can effectively interfere with the autoimmune reaction associated with EAE through mechanisms other than its antioxidant activity and supports further studies on the use of alpha-LA as a potential therapy for MS. PMID: 14975595 [PubMed - in process] ————————————————————————– —— Who  loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

Response:

You are seeing this message because Tom Hennessy aka ironjust…@aol.com has posted a message in alt.support.mult-sclerosis.  If you are new to this group then please see http://www.mikeswebsite.pwp.blueyonder.co.uk/amfFAQ.html#trolls before you accept that what he says has any merit.  You will find Tommy prominently featured. Sometimes Tommy stops to engage in scintillating repartee with newsgroup participants: http://tinyurl.com/2cflq  __ *