Talk Cancer

Question:

-tzara writes:

ps that was a joke And A funny one at that,  Thank you. My first thought was "Ok, So it bothers Chinese Hampsters.  Does it bother Americian Hampsters?"  and my second thought was "Hey I’m not a Hampster" —          "Nothing adds excitement to your life like something          that is clearly none of your business!"     Battista

Response:

: "THE DIETARY SUPPLEMENT CHROMIUM PICOLINATE INDUCES : CHROMOSOME DAMAGE IN CHINESE HAMSTER OVARY CELLS. : D.M. STEARNS; J.P. WISE, S.R. PATIERNO; AND K.E. WETTERHAHN : (SPON: Thomas A. Spencer, Jr.) Department of Chemistry, : Dartmouth College, Hanover, NH 03755; and Department of : Pharmacology, George Washington University, Washington, DC. : 20037 : Leslie Taylor This is simply not true. I have been feeding my chinese hamsters Chromium Picolinate for years and have not noticed any side effects at all! have fun -tzara ps that was a joke — Dada is like a dog- a compass- the abominal clay- neither new nor Japanese nude- a gas meter of sentiments rolled into pellets- Dada is brutal and puts out no propaganda- Dada is a quantity of life undergoing a transparent

Response:

Several people have requested this information and I thought it appropriate to post here as well. I just received this clinical trial in the mail today as well as a summary printed in the  FASEB Journal, Volume 9, Number 3 on March 8, 1995.  The following is their summary concerning a recent trial on cellular damage from non-toxic doses of Chromium Picolinate.  I now have the actual trial on hard copy and am in the process of converting it onto disk so that I can post it here or email it if requested.   I won’t try to interpret this for anyone, leaving the "experts" on this group to do so.  I can tell you all tho, that this report and trial has alarmed some labs and manufacturers of products containing Chromium Picolinate who are considering very quickly substituting Chromium nicotinate. The following is quoted from FASEB: "THE DIETARY SUPPLEMENT CHROMIUM PICOLINATE INDUCES CHROMOSOME DAMAGE IN CHINESE HAMSTER OVARY CELLS. D.M. STEARNS; J.P. WISE, S.R. PATIERNO; AND K.E. WETTERHAHN (SPON: Thomas A. Spencer, Jr.) Department of Chemistry, Dartmouth College, Hanover, NH 03755; and Department of Pharmacology, George Washington University, Washington, DC. 20037 Chromium (III) has been proposed to be an essential trace mineral in animals and humans, functioning in the maintenance of normal levels of glucose and lipid metabolism. Chromium supplements available to consumers include chromium (III) chloride (CRC13), chromium (III) nicotinate (CrNic) (U.S. Patent 5194615) and chromium (III) picolinate (CrPic) (U.S. patent 4315927). We are interested in the ability of chromium supplements to cause DNA damage. Chinese hamster ovary AA8 cells were treated with varying amounts of particulate CrPic or CrNic for 24 hours. Cytotoxicity was determined by measurement of colony formation.  Chromosome damage was measured as clastogenicity observed for cells in metaphase. Results were compared to those obtained in cells treated with ligands alone or with CrC13.  CrPic was found to cause significant chromosome damage at a non-toxic dose, and damage was dose-dependant.  Treatment with CrPic producing 91 +/- 12% colony survival resulted in 32 +/- 2% of metaphases with chromosome damage.  CrNic, CrC13 and nicotinate did not cause chromosome damage at equivalent doses.  Chromosome damage induced by CrPic was inferred to arise from the ligand since picolinate alone caused damage at a non-toxic dose.  This study raises the question of the safety of chromium picolinate as a human dietary supplement. (Funded by PHS Grants #CA 34896 and # CA 59292 National Cancer Institute)" I hope this is helpful.  If there’s enough interest, I’ll be happy to post the trial when its converted. Leslie Taylor

Response: